<p>This group contains proteins that are involved in chromosome condensation and segregation. They are distantly related to condensin subunit 1 (hCAP-D2) (<db_xref db="INTERPRO" dbkey="IPR007673"/>).</p> <p> <taxon tax_id="6239">Caenorhabditis elegans</taxon> holocentric protein 6 (HCP-6) is involved in regulation of chromosome condensation and functions to maintain chromosome rigidity and ensure accurate segregation [<cite idref="PUB00014711"/>]. Localised to the centromere, it is required to prevent chromosome twisting and merotelic attachment [<cite idref="PUB00014711"/>]. Both HCP-6 and condensin are required for chromosome organisation and segregation.</p> <p> <taxon tax_id="9606">Homo sapiens</taxon> (Human) HCP-6 (hHCP-6) is suggested to be dephosphorylated by protein phosphatase 2A (PP2A) [<cite idref="PUB00014710"/>]. Unlike condensin, hHCP-6 is Localised to the nucleus in interphase but, like condensin, hHCP-6 associates with chromosomes during mitosis. hHCP-6 is part of a complex that contains SMC2 and SMC4 (both of which are also components of condensin), kleisin-beta, and the HEAT repeat protein FLJ20311. hHCP-6 is therefore part of a condensin-related complex that associates with chromosomes in mitosis and may be regulated by PP2A [<cite idref="PUB00014710"/>].</p> Chromosome condensation protein, HCP-6-related